F45Y (p.Phe45Tyr) variant of MS4A1 (B-lymphocyte antigen CD20)
F45Y (p.Phe45Tyr) in MS4A1 (B-lymphocyte antigen CD20) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
F45Y (p.Phe45Tyr) variant details
- p.Phe45Tyr
- cosmic curated COSV61941
- Missense
- Variant Prioritization Score for Impact Estimate 0.37
- REVEL 0.22
- MetaLR 0.16
- MetaSVM -0.81
- CADD 25.50
- PolyPhen-2 0.99
- SIFT 0.01
- Most common in the 1KG:MXL population (allele frequency 0.0081)
- Structural context available