F45L (p.Phe45Leu) variant of MS4A1 (B-lymphocyte antigen CD20)
F45L (p.Phe45Leu) in MS4A1 (B-lymphocyte antigen CD20) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
F45L (p.Phe45Leu) variant details
- p.Phe45Leu
- cosmic curated COSV61942
- TOPMed rs1299992924
- gnomAD rs1299992924
- Missense
- Variant Prioritization Score for Impact Estimate 0.338
- REVEL 0.17
- MetaLR 0.09
- MetaSVM -1.09
- CADD 24.00
- PolyPhen-2 0.98
- SIFT 0.36
- Most common in the 1KG:CLM population (allele frequency 0.0053)
- Structural context available