A22V (p.Ala22Val) variant of MS4A1 (B-lymphocyte antigen CD20)
A22V (p.Ala22Val) in MS4A1 (B-lymphocyte antigen CD20) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.14 / 1. The record also includes population frequency data and structural context.
A22V (p.Ala22Val) variant details
- p.Ala22Val
- NCI-TCGA Cosmic COSV6194
- cosmic curated COSV61941
- Ensembl rs2135197243
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.136
- REVEL 0.00
- AlphaMissense 0.11
- MetaLR 0.04
- MetaSVM -1.01
- CADD 6.67
- PolyPhen-2 0.07
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Finnish in Finland (FIN) population (allele frequency 0.00019)
- Structural context available