V6G (p.Val6Gly) variant of MET (P08581)
V6G (p.Val6Gly) in MET (P08581) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Renal cell carcinoma. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
V6G (p.Val6Gly) variant details
- p.Val6Gly
- rs950885374
- ClinGen CA164887563
- ClinVar RCV003764428
- TOPMed rs950885374
- Uncertain significance
- Renal cell carcinoma
- Missense
- Variant Prioritization Score for Impact Estimate 0.303
- REVEL 0.14
- MetaLR 0.27
- MetaSVM -0.67
- CADD 17.60
- PolyPhen-2 0.07
- SIFT 0.15
- ClinVar: Uncertain significance (Renal cell carcinoma)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the 1KG:GIH population (allele frequency 0.0053)
- Structural context available