T17S (p.Thr17Ser) variant of MET (P08581)
T17S (p.Thr17Ser) in MET (P08581) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Hereditary cancer-predisposing syndrome; Renal cell carcinoma. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes published literature and structural context.
T17S (p.Thr17Ser) variant details
- p.Thr17Ser
- rs747777018
- ClinGen CA164887693
- ClinVar RCV001023537
- ClinVar RCV001223443
- Uncertain significance
- Hereditary cancer-predisposing syndrome; Renal cell carcinoma
- Missense
- Variant Prioritization Score for Impact Estimate 0.347
- AlphaMissense 0.09
- MetaLR 0.26
- MetaSVM -0.79
- PolyPhen-2 0.00
- SIFT 0.29
- EVE 0.11
- ClinVar: Uncertain significance (Hereditary cancer-predisposing syndrome; Renal cell carcinoma)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available
- Cited in: A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic… (PMID 25394175)