R21G (p.Arg21Gly) variant of MET (P08581)
R21G (p.Arg21Gly) in MET (P08581) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Renal cell carcinoma. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes structural context.
R21G (p.Arg21Gly) variant details
- p.Arg21Gly
- rs2116579265
- ClinGen CA368968254
- ClinVar RCV003593400
- Uncertain significance
- Renal cell carcinoma
- Missense
- Variant Prioritization Score for Impact Estimate 0.394
- AlphaMissense 0.12
- MetaLR 0.32
- MetaSVM -0.53
- PolyPhen-2 0.93
- SIFT 0.00
- EVE 0.20
- ClinVar: Uncertain significance (Renal cell carcinoma)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available