L18W (p.Leu18Trp) variant of MET (P08581)
L18W (p.Leu18Trp) in MET (P08581) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data, published literature, and structural context.
L18W (p.Leu18Trp) variant details
- p.Leu18Trp
- gnomAD 7-116699137-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.349
- REVEL 0.26
- MetaLR 0.58
- MetaSVM 0.21
- CADD 24.40
- PolyPhen-2 0.80
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 5.8e-05)
- Structural context available
- Literature evidence available