F16C (p.Phe16Cys) variant of MET (P08581)
F16C (p.Phe16Cys) in MET (P08581) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Hereditary cancer-predisposing syndrome; Renal cell carcinoma. The record also includes published literature and structural context.
F16C (p.Phe16Cys) variant details
- p.Phe16Cys
- rs2485504670
- ClinGen CA368968224
- ClinVar RCV003069436
- ClinVar RCV003161717
- Uncertain significance
- Hereditary cancer-predisposing syndrome; Renal cell carcinoma
- Missense
- ClinVar: Uncertain significance (Hereditary cancer-predisposing syndrome; Renal cell carcinoma)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available
- Cited in: A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic… (PMID 25394175)