C26Y (p.Cys26Tyr) variant of MET (P08581)
C26Y (p.Cys26Tyr) in MET (P08581) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of Renal cell carcinoma; Hereditary cancer-predisposing syndrome. The available variant effect predictions contribute to a CATVariant prioritization score of 0.68 / 1. The record also includes published literature and structural context.
C26Y (p.Cys26Tyr) variant details
- p.Cys26Tyr
- rs1584875719
- ClinGen CA368968291
- ClinVar RCV001026825
- ClinVar RCV005056791
- Uncertain significance
- Renal cell carcinoma; Hereditary cancer-predisposing syndrome
- Missense
- Variant Prioritization Score for Impact Estimate 0.676
- AlphaMissense 0.93
- MetaLR 0.61
- MetaSVM 0.22
- PolyPhen-2 1.00
- SIFT 0.00
- EVE 0.90
- ClinVar: Uncertain significance (Renal cell carcinoma; Hereditary cancer-predisposing syndrome)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Structural context available
- Cited in: A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic… (PMID 25394175)