K35R (p.Lys35Arg) variant of MCM3 (P25205)
K35R (p.Lys35Arg) in MCM3 (P25205) is a missense change. Clinical records from ClinVar and UniProt describe it as uncertain significance in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data.
K35R (p.Lys35Arg) variant details
- p.Lys35Arg
- ExAC rs745541606
- TOPMed rs745541606
- gnomAD rs745541606
- Uncertain significance
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.509
- CADD 23.40
- PolyPhen-2 0.02
- SIFT 0.32
- ClinVar: Uncertain significance (not specified)
- UniProt: Uncertain significance
- Most common in the Non-Finnish European population (allele frequency 3.6e-06)