T65A (p.Thr65Ala) variant of MBP (Myelin basic protein)
T65A (p.Thr65Ala) in MBP (Myelin basic protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
T65A (p.Thr65Ala) variant details
- p.Thr65Ala
- gnomAD rs1276378671
- Missense
- Variant Prioritization Score for Impact Estimate 0.313
- REVEL 0.19
- CADD 25.10
- PolyPhen-2 0.98
- SIFT 0.04
- Most common in the African/African-American population (allele frequency 0.00012)
- Structural context available