L35F (p.Leu35Phe) variant of MBP (Myelin basic protein)
L35F (p.Leu35Phe) in MBP (Myelin basic protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
L35F (p.Leu35Phe) variant details
- p.Leu35Phe
- ExAC rs780985755
- TOPMed rs780985755
- gnomAD rs780985755
- Missense
- Variant Prioritization Score for Impact Estimate 0.174
- REVEL 0.08
- CADD 12.80
- PolyPhen-2 0.01
- SIFT 0.06
- Most common in the Non-Finnish European population (allele frequency 2.9e-05)
- Structural context available