H4Y (p.His4Tyr) variant of MBP (Myelin basic protein)
H4Y (p.His4Tyr) in MBP (Myelin basic protein) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
H4Y (p.His4Tyr) variant details
- p.His4Tyr
- TOPMed rs947135999
- Missense
- Variant Prioritization Score for Impact Estimate 0.386
- REVEL 0.16
- CADD 23.60
- PolyPhen-2 0.93
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available