S25Y (p.Ser25Tyr) variant of MAP2K1 (Q02750)
S25Y (p.Ser25Tyr) in MAP2K1 (Q02750) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.59 / 1. The record also includes population frequency data, published literature, and structural context.
S25Y (p.Ser25Tyr) variant details
- p.Ser25Tyr
- gnomAD 15-66387421-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.586
- REVEL 0.49
- MetaLR 0.65
- MetaSVM 0.34
- CADD 22.80
- PolyPhen-2 0.31
- SIFT 0.04
- Population evidence available
- Structural context available
- Literature evidence available