S25F (p.Ser25Phe) variant of MAP2K1 (Q02750)
S25F (p.Ser25Phe) in MAP2K1 (Q02750) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.57 / 1. The record also includes population frequency data and structural context.
S25F (p.Ser25Phe) variant details
- p.Ser25Phe
- 1000Genomes rs553162958
- ExAC rs553162958
- gnomAD rs553162958
- Missense
- Variant Prioritization Score for Impact Estimate 0.566
- REVEL 0.49
- MetaLR 0.55
- MetaSVM 0.10
- CADD 23.20
- PolyPhen-2 0.23
- SIFT 0.05
- Most common in the 1KG:BEB population (allele frequency 0.0051)
- Structural context available