S24R (p.Ser24Arg) variant of MAP2K1 (Q02750)
S24R (p.Ser24Arg) in MAP2K1 (Q02750) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
S24R (p.Ser24Arg) variant details
- p.Ser24Arg
- gnomAD 15-66387419-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.445
- REVEL 0.41
- MetaLR 0.60
- MetaSVM -0.05
- CADD 22.10
- PolyPhen-2 0.04
- SIFT 0.24
- Population evidence available
- Structural context available
- Dabrafenib and Cetuximab HT-29 cells, base editing z-scores (predicted consequen: score 0.126
- Literature evidence available