P8L (p.Pro8Leu) variant of MAP2K1 (Q02750)
P8L (p.Pro8Leu) in MAP2K1 (Q02750) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data, published literature, and structural context.
P8L (p.Pro8Leu) variant details
- p.Pro8Leu
- gnomAD 15-66387370-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.53
- REVEL 0.40
- MetaLR 0.63
- MetaSVM 0.11
- CADD 24.10
- PolyPhen-2 0.17
- SIFT 0.13
- Population evidence available
- Structural context available
- Literature evidence available