P15L (p.Pro15Leu) variant of MAP2K1 (Q02750)
P15L (p.Pro15Leu) in MAP2K1 (Q02750) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data and structural context.
P15L (p.Pro15Leu) variant details
- p.Pro15Leu
- ExAC rs764535990
- gnomAD rs764535990
- Missense
- Variant Prioritization Score for Impact Estimate 0.54
- REVEL 0.43
- MetaLR 0.59
- MetaSVM 0.16
- CADD 22.90
- PolyPhen-2 0.06
- SIFT 0.12
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available