N21K (p.Asn21Lys) variant of MAP2K1 (Q02750)
N21K (p.Asn21Lys) in MAP2K1 (Q02750) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data, published literature, and structural context.
N21K (p.Asn21Lys) variant details
- p.Asn21Lys
- gnomAD 15-66387410-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.436
- REVEL 0.39
- MetaLR 0.52
- MetaSVM 0.02
- CADD 22.60
- PolyPhen-2 0.26
- SIFT 0.18
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available
- Literature evidence available