L11P (p.Leu11Pro) variant of MAP2K1 (Q02750)
L11P (p.Leu11Pro) in MAP2K1 (Q02750) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
L11P (p.Leu11Pro) variant details
- p.Leu11Pro
- gnomAD 15-66387379-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.488
- REVEL 0.41
- MetaLR 0.64
- MetaSVM 0.04
- CADD 24.70
- PolyPhen-2 0.01
- SIFT 0.04
- Population evidence available
- Structural context available
- Trametinib HT-29 cells, base editing z-scores (predicted consequence): score -0.63
- Literature evidence available