I9T (p.Ile9Thr) variant of MAP2K1 (Q02750)
I9T (p.Ile9Thr) in MAP2K1 (Q02750) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
I9T (p.Ile9Thr) variant details
- p.Ile9Thr
- gnomAD 15-66387373-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.533
- REVEL 0.52
- MetaLR 0.58
- MetaSVM 0.04
- CADD 23.10
- PolyPhen-2 0.14
- SIFT 0.13
- Population evidence available
- Structural context available
- Dabrafenib and Cetuximab HT-29 cells, base editing z-scores (predicted consequen: score 0.0261
- Literature evidence available