G22W (p.Gly22Trp) variant of MAP2K1 (Q02750)
G22W (p.Gly22Trp) in MAP2K1 (Q02750) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.77 / 1. The record also includes population frequency data and structural context.
G22W (p.Gly22Trp) variant details
- p.Gly22Trp
- TOPMed rs994693514
- Missense
- Variant Prioritization Score for Impact Estimate 0.77
- REVEL 0.76
- MetaLR 0.74
- MetaSVM 0.58
- CADD 31.00
- PolyPhen-2 0.76
- SIFT 0.01
- Most common in the East Asian population (allele frequency 2.7e-05)
- Structural context available