G22V (p.Gly22Val) variant of MAP2K1 (Q02750)
G22V (p.Gly22Val) in MAP2K1 (Q02750) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.56 / 1. The record also includes population frequency data, published literature, and structural context.
G22V (p.Gly22Val) variant details
- p.Gly22Val
- gnomAD 15-66387412-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.561
- REVEL 0.48
- MetaLR 0.63
- MetaSVM 0.08
- CADD 23.10
- PolyPhen-2 0.04
- SIFT 0.19
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available