D16G (p.Asp16Gly) variant of MAP2K1 (Q02750)
D16G (p.Asp16Gly) in MAP2K1 (Q02750) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
D16G (p.Asp16Gly) variant details
- p.Asp16Gly
- gnomAD 15-66387394-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.44
- REVEL 0.34
- MetaLR 0.59
- MetaSVM -0.07
- CADD 23.30
- PolyPhen-2 0.03
- SIFT 0.18
- Population evidence available
- Structural context available
- Trametinib HT-29 cells, base editing z-scores (predicted consequence): score 0.408
- Literature evidence available