A19T (p.Ala19Thr) variant of MAP2K1 (Q02750)
A19T (p.Ala19Thr) in MAP2K1 (Q02750) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
A19T (p.Ala19Thr) variant details
- p.Ala19Thr
- gnomAD 15-66387402-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.446
- REVEL 0.35
- MetaLR 0.47
- MetaSVM -0.38
- CADD 20.60
- PolyPhen-2 0.00
- SIFT 0.69
- Population evidence available
- Structural context available
- Dabrafenib and Cetuximab HT-29 cells, base editing z-scores (predicted consequen: score 0.944
- Literature evidence available