T34M (p.Thr34Met) variant of LRRK2 (Q5S007)
T34M (p.Thr34Met) in LRRK2 (Q5S007) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
T34M (p.Thr34Met) variant details
- p.Thr34Met
- gnomAD rs1285731382
- Missense
- Variant Prioritization Score for Impact Estimate 0.394
- REVEL 0.15
- MetaLR 0.24
- MetaSVM -0.65
- CADD 27.10
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available