S5G (p.Ser5Gly) variant of LRRK2 (Q5S007)
S5G (p.Ser5Gly) in LRRK2 (Q5S007) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.17 / 1. The record also includes population frequency data and structural context.
S5G (p.Ser5Gly) variant details
- p.Ser5Gly
- TOPMed rs1307608899
- Missense
- Variant Prioritization Score for Impact Estimate 0.173
- REVEL 0.13
- MetaLR 0.06
- MetaSVM -1.03
- CADD 20.30
- PolyPhen-2 0.00
- SIFT 0.24
- Most common in the Non-Finnish European population (allele frequency 9.9e-07)
- Structural context available