S3T (p.Ser3Thr) variant of LRRK2 (Q5S007)
S3T (p.Ser3Thr) in LRRK2 (Q5S007) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data, published literature, and structural context.
S3T (p.Ser3Thr) variant details
- p.Ser3Thr
- gnomAD 12-40225139-G-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.296
- REVEL 0.14
- MetaLR 0.17
- MetaSVM -0.90
- CADD 24.60
- PolyPhen-2 0.84
- SIFT 0.11
- Population evidence available
- Structural context available
- Literature evidence available