Q31R (p.Gln31Arg) variant of LRRK2 (Q5S007)
Q31R (p.Gln31Arg) in LRRK2 (Q5S007) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, published literature, and structural context.
Q31R (p.Gln31Arg) variant details
- p.Gln31Arg
- gnomAD 12-40225223-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.281
- REVEL 0.24
- MetaLR 0.09
- MetaSVM -0.98
- CADD 23.40
- PolyPhen-2 0.00
- SIFT 0.17
- Most common in the African/African-American population (allele frequency 2.8e-05)
- Structural context available
- Literature evidence available