P63S (p.Pro63Ser) variant of LRRK2 (Q5S007)
P63S (p.Pro63Ser) in LRRK2 (Q5S007) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
P63S (p.Pro63Ser) variant details
- p.Pro63Ser
- TOPMed rs894713683
- gnomAD rs894713683
- Missense
- Variant Prioritization Score for Impact Estimate 0.294
- REVEL 0.14
- MetaLR 0.12
- MetaSVM -1.02
- CADD 23.50
- PolyPhen-2 0.50
- SIFT 0.05
- Most common in the HGDP:MBUTI population (allele frequency 0.083)
- Structural context available