L68W (p.Leu68Trp) variant of LRRK2 (Q5S007)
L68W (p.Leu68Trp) in LRRK2 (Q5S007) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data, published literature, and structural context.
L68W (p.Leu68Trp) variant details
- p.Leu68Trp
- gnomAD 12-40225606-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.389
- REVEL 0.20
- MetaLR 0.41
- MetaSVM -0.15
- CADD 29.50
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Ashkenazi Jewish population (allele frequency 7.7e-05)
- Structural context available
- Literature evidence available