L68M (p.Leu68Met) variant of LRRK2 (Q5S007)
L68M (p.Leu68Met) in LRRK2 (Q5S007) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data, published literature, and structural context.
L68M (p.Leu68Met) variant details
- p.Leu68Met
- gnomAD 12-40225605-T-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.253
- REVEL 0.22
- MetaLR 0.33
- MetaSVM -0.56
- CADD 22.60
- PolyPhen-2 0.98
- SIFT 0.02
- Population evidence available
- Structural context available
- Literature evidence available