L64M (p.Leu64Met) variant of LRRK2 (Q5S007)
L64M (p.Leu64Met) in LRRK2 (Q5S007) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data, published literature, and structural context.
L64M (p.Leu64Met) variant details
- p.Leu64Met
- gnomAD 12-40225593-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.338
- REVEL 0.12
- MetaLR 0.26
- MetaSVM -0.43
- CADD 24.50
- PolyPhen-2 0.49
- SIFT 0.00
- Population evidence available
- Structural context available
- Literature evidence available