L39M (p.Leu39Met) variant of LRRK2 (Q5S007)
L39M (p.Leu39Met) in LRRK2 (Q5S007) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
L39M (p.Leu39Met) variant details
- p.Leu39Met
- gnomAD rs1455437751
- Missense
- Variant Prioritization Score for Impact Estimate 0.296
- REVEL 0.13
- MetaLR 0.31
- MetaSVM -0.36
- CADD 25.80
- PolyPhen-2 0.91
- SIFT 0.13
- Most common in the Finnish in Finland (FIN) population (allele frequency 3.8e-05)
- Structural context available