I60T (p.Ile60Thr) variant of LRRK2 (Q5S007)
I60T (p.Ile60Thr) in LRRK2 (Q5S007) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data, published literature, and structural context.
I60T (p.Ile60Thr) variant details
- p.Ile60Thr
- gnomAD 12-40225582-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.207
- REVEL 0.04
- MetaLR 0.07
- MetaSVM -1.01
- CADD 23.00
- PolyPhen-2 0.01
- SIFT 0.04
- Population evidence available
- Structural context available
- Literature evidence available