I60F (p.Ile60Phe) variant of LRRK2 (Q5S007)
I60F (p.Ile60Phe) in LRRK2 (Q5S007) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data, published literature, and structural context.
I60F (p.Ile60Phe) variant details
- p.Ile60Phe
- gnomAD 12-40225581-A-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.162
- REVEL 0.04
- MetaLR 0.04
- MetaSVM -1.05
- CADD 18.80
- PolyPhen-2 0.00
- SIFT 0.09
- Population evidence available
- Structural context available
- Literature evidence available