G4A (p.Gly4Ala) variant of LRRK2 (Q5S007)
G4A (p.Gly4Ala) in LRRK2 (Q5S007) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
G4A (p.Gly4Ala) variant details
- p.Gly4Ala
- ExAC rs747338046
- TOPMed rs747338046
- gnomAD rs747338046
- Missense
- Variant Prioritization Score for Impact Estimate 0.218
- REVEL 0.05
- MetaLR 0.09
- MetaSVM -0.95
- CADD 23.10
- PolyPhen-2 0.04
- SIFT 0.05
- Most common in the 1KG:GIH population (allele frequency 0.0053)
- Structural context available