E10G (p.Glu10Gly) variant of LRRK2 (Q5S007)
E10G (p.Glu10Gly) in LRRK2 (Q5S007) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data, published literature, and structural context.
E10G (p.Glu10Gly) variant details
- p.Glu10Gly
- gnomAD 12-40225160-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.182
- REVEL 0.07
- MetaLR 0.10
- MetaSVM -0.99
- CADD 24.20
- PolyPhen-2 0.17
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 4.5e-06)
- Structural context available
- Literature evidence available