D41G (p.Asp41Gly) variant of LRRK2 (Q5S007)
D41G (p.Asp41Gly) in LRRK2 (Q5S007) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data, published literature, and structural context.
D41G (p.Asp41Gly) variant details
- p.Asp41Gly
- gnomAD 12-40225253-A-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.416
- REVEL 0.34
- MetaLR 0.11
- MetaSVM -0.98
- CADD 26.40
- PolyPhen-2 0.07
- SIFT 0.00
- Most common in the 1KG:GIH population (allele frequency 0.0053)
- Structural context available
- Literature evidence available