Y40N (p.Tyr40Asn) variant of LPA (Apolipoprotein(a))
Y40N (p.Tyr40Asn) in LPA (Apolipoprotein(a)) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.23 / 1. The record also includes population frequency data and structural context.
Y40N (p.Tyr40Asn) variant details
- p.Tyr40Asn
- Ensembl rs1562352927
- Missense
- Variant Prioritization Score for Impact Estimate 0.234
- REVEL 0.04
- MetaLR 0.04
- MetaSVM -1.02
- CADD 14.80
- PolyPhen-2 0.94
- SIFT 0.32
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available