W52L (p.Trp52Leu) variant of LPA (Apolipoprotein(a))
W52L (p.Trp52Leu) in LPA (Apolipoprotein(a)) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.61 / 1. The record also includes population frequency data and structural context.
W52L (p.Trp52Leu) variant details
- p.Trp52Leu
- ExAC rs751841836
- gnomAD rs751841836
- Missense
- Variant Prioritization Score for Impact Estimate 0.606
- REVEL 0.45
- MetaLR 0.92
- MetaSVM 0.51
- CADD 23.90
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available