T43S (p.Thr43Ser) variant of LPA (Apolipoprotein(a))
T43S (p.Thr43Ser) in LPA (Apolipoprotein(a)) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
T43S (p.Thr43Ser) variant details
- p.Thr43Ser
- ExAC rs747664654
- gnomAD rs747664654
- Missense
- Variant Prioritization Score for Impact Estimate 0.464
- REVEL 0.33
- MetaLR 0.38
- MetaSVM -0.66
- CADD 19.90
- PolyPhen-2 0.97
- SIFT 0.03
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available