S35R (p.Ser35Arg) variant of LPA (Apolipoprotein(a))
S35R (p.Ser35Arg) in LPA (Apolipoprotein(a)) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
S35R (p.Ser35Arg) variant details
- p.Ser35Arg
- 1000Genomes rs200491482
- ExAC rs200491482
- TOPMed rs200491482
- gnomAD rs200491482
- Missense
- Variant Prioritization Score for Impact Estimate 0.267
- REVEL 0.13
- MetaLR 0.25
- MetaSVM -0.83
- CADD 15.00
- PolyPhen-2 0.92
- SIFT 0.07
- Most common in the HGDP:ORCADIAN population (allele frequency 0.036)
- Structural context available