S22N (p.Ser22Asn) variant of LPA (Apolipoprotein(a))
S22N (p.Ser22Asn) in LPA (Apolipoprotein(a)) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
S22N (p.Ser22Asn) variant details
- p.Ser22Asn
- ExAC rs754876758
- gnomAD rs754876758
- Missense
- Variant Prioritization Score for Impact Estimate 0.177
- REVEL 0.03
- MetaLR 0.06
- MetaSVM -1.02
- CADD 0.97
- PolyPhen-2 0.06
- SIFT 0.40
- Most common in the South Asian population (allele frequency 5.8e-05)
- Structural context available