M55L (p.Met55Leu) variant of LPA (Apolipoprotein(a))
M55L (p.Met55Leu) in LPA (Apolipoprotein(a)) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.27 / 1. The record also includes population frequency data and structural context.
M55L (p.Met55Leu) variant details
- p.Met55Leu
- 1000Genomes rs375385826
- ESP rs375385826
- ExAC rs375385826
- TOPMed rs375385826
- Missense
- Variant Prioritization Score for Impact Estimate 0.27
- REVEL 0.19
- MetaLR 0.14
- MetaSVM -0.78
- CADD 16.20
- PolyPhen-2 0.68
- SIFT 0.24
- Most common in the Non-Finnish European population (allele frequency 5.4e-06)
- Structural context available