L8F (p.Leu8Phe) variant of LPA (Apolipoprotein(a))
L8F (p.Leu8Phe) in LPA (Apolipoprotein(a)) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.20 / 1. The record also includes population frequency data and structural context.
L8F (p.Leu8Phe) variant details
- p.Leu8Phe
- TOPMed rs1482010159
- gnomAD rs1482010159
- Missense
- Variant Prioritization Score for Impact Estimate 0.199
- REVEL 0.06
- MetaLR 0.32
- MetaSVM -0.67
- CADD 17.90
- PolyPhen-2 0.47
- SIFT 0.19
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available