L10P (p.Leu10Pro) variant of LPA (Apolipoprotein(a))
L10P (p.Leu10Pro) in LPA (Apolipoprotein(a)) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data and structural context.
L10P (p.Leu10Pro) variant details
- p.Leu10Pro
- TOPMed rs1252113389
- gnomAD rs1252113389
- Missense
- Variant Prioritization Score for Impact Estimate 0.478
- REVEL 0.41
- MetaLR 0.38
- MetaSVM -0.63
- CADD 25.40
- PolyPhen-2 0.81
- SIFT 0.15
- Most common in the Latino/Admixed American population (allele frequency 0.00026)
- Structural context available