K4R (p.Lys4Arg) variant of LPA (Apolipoprotein(a))
K4R (p.Lys4Arg) in LPA (Apolipoprotein(a)) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
K4R (p.Lys4Arg) variant details
- p.Lys4Arg
- TOPMed rs1031996107
- gnomAD rs1031996107
- Missense
- Variant Prioritization Score for Impact Estimate 0.147
- REVEL 0.09
- MetaLR 0.22
- MetaSVM -0.84
- CADD 12.00
- PolyPhen-2 0.44
- SIFT 0.30
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available