H58Y (p.His58Tyr) variant of LPA (Apolipoprotein(a))
H58Y (p.His58Tyr) in LPA (Apolipoprotein(a)) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
H58Y (p.His58Tyr) variant details
- p.His58Tyr
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.455
- REVEL 0.37
- MetaLR 0.34
- MetaSVM -0.74
- CADD 23.60
- PolyPhen-2 0.99
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 3e-05)
- Structural context available