H23Y (p.His23Tyr) variant of LPA (Apolipoprotein(a))
H23Y (p.His23Tyr) in LPA (Apolipoprotein(a)) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.34 / 1. The record also includes population frequency data and structural context.
H23Y (p.His23Tyr) variant details
- p.His23Tyr
- Ensembl rs1562352980
- Missense
- Variant Prioritization Score for Impact Estimate 0.344
- REVEL 0.15
- MetaLR 0.19
- MetaSVM -0.89
- CADD 13.90
- PolyPhen-2 0.39
- SIFT 1.00
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available